FURTHER EVIDENCE FOR NEGATIVE INOTROPIC ACTION OF ACETYLCHOLINE
نویسندگان
چکیده
منابع مشابه
A two-compartment model describing the release and negative inotropic action of acetylcholine on the heart.
Single-pulse stimulation of the vagus nerve in turtles (Pseudyrnys jloridana) produced the well-known negative inotropic effect on the atria. After stimulation, the peak amplitudes of the atrial contractions exhibited an envelope which appeared to be proportional to the concentration of acetylcholine at the receptor sites. Postulating a quantized release of acetylcholine with each stimulus, the...
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The effects of acetylcholine and nicotine on isometric tension, in the presence and absence of atropine, hexamethonium, and endogenous norepinephrine stores, were examined in isolated cat atria and papillary muscles. Acetylcholine exerted a negative inotropic effect, competitively inhibited by atropine, in atrial and papillary muscle; in higher concentrations in papillary muscles, it produced a...
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Administration of isotonic THAM to the blood of the heart-lung preparation induced a decrease in the negative inotropic effect of CO2, suggested by the fact that, at constant stroke work, an increase in Pco2 of 26 ± 1.9 mm Hg was followed by an increase in left ventricular end-diastolic pressure (LVEDP) of 3.8 ± 0.2 mm Hg before the infusion of THAM; after THAM was given, a similar increase in ...
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ژورنال
عنوان ژورنال: The Japanese Journal of Pharmacology
سال: 1973
ISSN: 0021-5198,1347-3506
DOI: 10.1254/jjp.23.299